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Ipratropium Bromide

Presentation
  • 250 mcg in 1 mL nebule or polyamp
Pharmacology

Anticholinergic bronchodilator

Actions:

  • Allows bronchodilatation by inhibiting cholinergic bronchomotor tone (i.e. blocks vagal reflexes which mediate bronchoconstriction)
Metabolism

Excreted by the kidneys

  1. Severe respiratory distress associated with bronchospasm
  2. Exacerbation of COPD irrespective of severity
  1. Known hypersensitivity to Atropine or its derivatives
  1. Glaucoma
  2. Avoid contact with eyes
Route of administration
  • Headache
  • Nausea
  • Dry mouth
  • Skin rash
  • Tachycardia (rare)
  • Palpitations (rare)
  • Acute angle closure glaucoma secondary to direct eye contact (rare)
Special Notes

There have been isolated reports of ocular complications (dilated pupils,
increased intraocular pressure, acute angle glaucoma, eye pain) as a result of
direct eye contact with Ipratropium Bromide formulations.

The nebuliser mask must therefore be fitted properly during inhalation and care
taken to avoid Ipratropium Bromide solution entering the eyes.

Ipratropium Bromide must be nebulised in conjunction with Salbutamol and is
to be administered as a single dose only.

Onset: 3 – 5 minutes
Peak: 1.5 – 2 hours
Duration: 6 hours

Quiz