Home Midazolam

Midazolam

Presentation
  • 5 mg in 1 mL glass ampoule
  • 15 mg in 3 mL glass ampoule
Pharmacology

Short acting CNS depressant

Actions:

  • Anxiolytic
  • Sedative
  • Anti-convulsant
Metabolism

In the liver; excreted by the kidneys

  1. Status epilepticus
  2. Sedation to maintain intubation
  3. Sedation to facilitate intubation (RSI – modified or Paediatric IFS)
  4. Sedation to facilitate synchronised cardioversion
  5. Sedation to facilitate transthoracic pacing
  6. Sedation in the agitated patient (including patients under the Mental Health Act 2014)
  7. Sedation in psychostimulant OD
  1. Known hypersensitivity to benzodiazepines
  1. Elderly / frail patients
  2. Patients with cardiovascular disease
  3. Patients on monoamine oxidase inhibitors
  4. Higher doses may be required for patients on beta blockers
Route of administration
  • IM
  • IV
  • IV infusion
  • Depressed level of consciousness
  • Respiratory depression
  • Loss of airway control
  • Hypotension
Special Notes

IM Effects

Onset: 3 – 5 minutes
Peak: 15 minutes
Duration: 30 minutes

IV Effects

Onset: 1 – 3 minutes
Peak: 10 minutes
Duration: 20 minutes

Quiz