Details
Presentation:
3 mL bottle
Route:
Self-administered via inhalation using Penthrox inhaler device. Can be used intermittently or continuously as required
Onset of action:
Within 6 to 10 breaths
Duration:
Effects last 3 – 5 minutes after stopping the inhalation. One vial provides up to 25 minutes of analgesia with continuous use
Mode of action
Inhaled anaesthetic – produces analgesia at low concentrations, however the exact mode of action is unknown
- Analgesia
- Pre-existing renal disease (see Notes below)
- Known (or genetic susceptibility) to malignant hyperthermia
- Patients should not be administered > 6 mL of methoxyflurane in a 24 hour period, due to increased risk of nephrotoxicity
- To limit occupational exposure, methoxyflurane should not be administered in a confined space. Ensure adequate ventilation in ambulance. Place used Penthrox inhalers in a closed plastic bag when not in use.
- CNS: Dizziness, drowsiness
- CV: Hypotension
- GIT: Nausea and vomiting
Significant interactions
- Unlikely when administered as directed
Pregnancy
- Considered safe to use
- Considered safe to use
Notes
- Managed as a restricted medication in AV
- Pre-existing renal disease includes previously diagnosed renal impairment or failure. Kidney stones and/or renal colic are not contraindications to methoxyflurane therapy within the context of this guideline
Infusion
- None