Home Methoxyflurane

Methoxyflurane

Details

Presentation:

3 mL bottle

Route:

Self-administered via inhalation using Penthrox inhaler device. Can be used intermittently or continuously as required

Onset of action:

Within 6 to 10 breaths

Duration:

Effects last 3 – 5 minutes after stopping the inhalation. One vial provides up to 25 minutes of analgesia with continuous use

Mode of action

Inhaled anaesthetic – produces analgesia at low concentrations, however the exact mode of action is unknown

  • Pre-existing renal disease (see Notes below)
  • Known (or genetic susceptibility) to malignant hyperthermia
  • Patients should not be administered > 6 mL of methoxyflurane in a 24 hour period, due to increased risk of nephrotoxicity
  • To limit occupational exposure, methoxyflurane should not be administered in a confined space. Ensure adequate ventilation in ambulance. Place used Penthrox inhalers in a closed plastic bag when not in use.
Significant interactions
  • Unlikely when administered as directed
Pregnancy
  • Considered safe to use
Breastfeeding
  • Considered safe to use
Notes
  • Managed as a restricted medication in AV
  • Pre-existing renal disease includes previously diagnosed renal impairment or failure. Kidney stones and/or renal colic are not contraindications to methoxyflurane therapy within the context of this guideline
Infusion
  • None

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