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Ceftriaxone

Presentation
  • 1 g sterile powder in a glass vial
Pharmacology

Cephalosporin antibiotic

Metabolism

Excreted unchanged in urine (33% – 67%) and in bile

  1. Suspected meningococcal septicaemia
  2. Severe sepsis (consult only)
  1. Allergy to Cephalosporin antibiotics
  1. Allergy to Penicillin antibiotics
Route of administration
  • IV (preferred)
  • IM (if IV access unavailable)
Special Notes

Usual dose: Adult 1 g, Child 50 mg/kg (max 1 g)

Ceftriaxone IV

IV must be made up to 10 mL using sterile water and dose administered over 2 minutes

Ceftriaxone IM

IM must be made up to 4 mL using 1% Lignocaine and dose administered in lateral upper thigh

IM/IV effects:
Onset: n/a
Peak: n/a
Duration: n/a

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