Presentation
- 5 mg ODT
Mode of action
Atypical antipsychotic – antagonist at multiple receptor sites, particularly
serotonin (5-HT), dopamine, and histamine
- Mild agitation
- Olanzapine may be less effective if patient agitation is due to drug intoxication (especially stimulants) or alcohol withdrawal. Benzodiazepines are considered first-line agents in these patients
- Elderly / frail patients and children are more susceptible to adverse effects
Significant interactions
- Sedative medications / alcohol – over sedation due to synergistic effects. Avoid combination where possible
- Sedation, dizziness
- Extrapyramidal symptoms and QT prolongation are unlikely when administered at the approved doses
Administration advice
Route of administration: Oral – ODT is dissolved in the mouth and then
swallowed
Onset of action: 15 mins
Duration of action: 12 – 24 hours
Pregnancy & breastfeeding category
Pregnancy: Limited evidence. Administer only if benefit outweighs risk
Breastfeeding: Considered safe to use
AV Special notes
Administration to patients < 16 years of age can only occur after consultation with the receiving hospital.
The patient should self-administer the dose under paramedic supervision.
Olanzapine is managed as a restricted medication in AV.
Olanzapine and Ondansetron ODTs are similar in name and presentation. Extra care must be taken to ensure the right medication is selected prior to administration
Infusion information
N/A