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Olanzapine

Presentation
  • 5 mg ODT
Mode of action

Atypical antipsychotic – antagonist at multiple receptor sites, particularly
serotonin (5-HT), dopamine, and histamine

  1. Olanzapine may be less effective if patient agitation is due to drug intoxication (especially stimulants) or alcohol withdrawal. Benzodiazepines are considered first-line agents in these patients
  2. Elderly / frail patients and children are more susceptible to adverse effects
Significant interactions
  1. Sedative medications / alcohol – over sedation due to synergistic effects. Avoid combination where possible
CNS:
  • Sedation, dizziness
Other:
  • Extrapyramidal symptoms and QT prolongation are unlikely when administered at the approved doses
Administration advice

Route of administration: Oral – ODT is dissolved in the mouth and then
swallowed

Onset of action: 15 mins

Duration of action: 12 – 24 hours

Pregnancy & breastfeeding category

Pregnancy: Limited evidence. Administer only if benefit outweighs risk

Breastfeeding: Considered safe to use

AV Special notes

Administration to patients < 16 years of age can only occur after consultation with the receiving hospital.

The patient should self-administer the dose under paramedic supervision.

Olanzapine is managed as a restricted medication in AV.

Olanzapine and Ondansetron ODTs are similar in name and presentation. Extra care must be taken to ensure the right medication is selected prior to administration

Infusion information

N/A

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