Presentation
- 300 mg chewable tablet
- 300 mg soluble or water dispersible tablets
Pharmacology
An analgesic, antipyretic, anti-inflammatory and antiplatelet aggregation agent
Actions:
- To minimise platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombosis in ACS
- Inhibits synthesis of prostaglandins – anti-inflammatory actions
Metabolism
Converted to salicylate in the gut mucosa and liver; excreted mainly by the
kidneys
- Hypersensitivity to aspirin / salicylates
- Actively bleeding peptic ulcers
- Bleeding disorders
- Suspected dissecting aortic aneurysm
- Chest pain associated with psychostimulant OD if SBP >160 mmHg
- Peptic ulcer
- Asthma
- Patients on anticoagulants
Route of administration
- Oral
- Heartburn, nausea, gastrointestinal bleeding
- Increased bleeding time
- Hypersensitivity reactions
Special Notes
Aspirin is C/I for use in acute febrile illness in children and adolescents. The anti-platelet effects of Aspirin persist for the natural life of platelets.
Onset: n/a
Peak: n/a
Duration: 8 – 10 days